Asset Details
Do you wish to reserve the book?
2962 Paraneoplastic progressive encephalomyelitis with rigidity and myoclonus associated with monoclonal B-cell lymphocytosis in the setting of longstanding methotrexate use
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
2962 Paraneoplastic progressive encephalomyelitis with rigidity and myoclonus associated with monoclonal B-cell lymphocytosis in the setting of longstanding methotrexate use
Do you wish to request the book?
2962 Paraneoplastic progressive encephalomyelitis with rigidity and myoclonus associated with monoclonal B-cell lymphocytosis in the setting of longstanding methotrexate use
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
2962 Paraneoplastic progressive encephalomyelitis with rigidity and myoclonus associated with monoclonal B-cell lymphocytosis in the setting of longstanding methotrexate use
2024
Overview
BackgroundProgressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare but debilitating disease within the stiff-person syndrome (SPS) spectrum and is characterised by muscle rigidity, spasms, myoclonus, dysautonomia and brainstem dysfunction. The exact pathogenetic mechanism is unclear, although there is an association with the presence of glycine receptor antibodies in serum and cerebrospinal fluid, and some cases are paraneoplastic.ResultsHere we report a complex case of paraneoplastic PERM associated with an otherwise subclinical monoclonal B-cell lymphocytosis (MBL) of the non-chronic lymphocytic leukaemia (CLL) phenotype, which may be in turn likely secondary to long-term methotrexate use (i.e. methotrexate-associated lymphoproliferative disorder, MTX-LPD) or underlying autoimmune disease.ConclusionsPERM often has a paraneoplastic aetiology and likely exerts antitumour response against malignancies, thus potentially rendering the primary malignancies indolent or atypical in presentation. This is, to our knowledge, the first reported association between PERM and MBL, or between PERM and MTX-LPD.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
