Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

by Cai, Xunhui , Tong, Amy Hin Yan , Nedyalkova, Lyudmila , Usaj, Matej , Mair, Barbara , Shuteriqi, Emira , Almeida, Sylvia M T , Zhang, Xiang , Hassan, Arshia Z , van Leeuwen, Jolanda , Thomson Taylor, David , Dixon, Scott J , Tieu, David , Billmann, Maximilian , Bhojoo, Urvi , Davis, Nicholas G , Kim, Dae-Kyum , Horecka, Ira , Liang, Wendy , Moffat, Jason , Tan, Guihong , Aguilera-Uribe, Magali , Brown, Grant W , Mikolajewicz, Nicholas , Andrews, Brenda , Aregger, Michael , Aulakh, Kamaldeep , Pons, Carles , Masud, Sanna N , Lee, Yoonkyu , Chang, Daniel , Seetharaman, Ashwin , Forster, Duncan , Loewith, Robbie , Ward, Henry N , Ross, Catherine , Budijono, Nathaniel , Nami, Babak , Sizova, Olga , Kantautas, Kristin , Chan, Katherine S , Climie, Ryan , Rojas Echenique, Jose I , Ubhi, Tajinder , Granda Farias, Adrian , Wang, Zi Yang , Lu, Xueibing , Lin, Kevin , Ji, Fenghu , Soste, Martin , Boone, Charles , Wang, Wen , Roth, Frederick P , Lawson, Keith A , Lim, Julianne , Rohde, Thomas , Brown, Kevin R , Sartori Rodrigues, Maria , Birkadze, Saba , Drazic, Adrian , Nixon, Allison , Myers, Chad L , Wei, Jiarun , Cravatt, Benjamin F , Roth, Amy F , Bader, Gary D , Turowec, Jacob , Lee, Se

in Systems Biology

2025

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

in Systems Biology

2025

Confirm

Do you wish to request the book?

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

in Systems Biology

2025

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

Cai, Xunhui,

Tong, Amy Hin Yan,

Nedyalkova, Lyudmila,

Usaj, Matej,

Mair, Barbara,

Shuteriqi, Emira,

Almeida, Sylvia M T,

Zhang, Xiang,

Hassan, Arshia Z,

van Leeuwen, Jolanda,

Thomson Taylor, David,

Dixon, Scott J,

Tieu, David,

Billmann, Maximilian,

Bhojoo, Urvi,

Davis, Nicholas G,

Kim, Dae-Kyum,

Horecka, Ira,

Liang, Wendy,

Moffat, Jason,

Tan, Guihong,

Aguilera-Uribe, Magali,

Brown, Grant W,

Mikolajewicz, Nicholas,

Andrews, Brenda,

Aregger, Michael,

Aulakh, Kamaldeep,

Pons, Carles,

Masud, Sanna N,

Lee, Yoonkyu,

Chang, Daniel,

Seetharaman, Ashwin,

Forster, Duncan,

Loewith, Robbie,

Ward, Henry N,

Ross, Catherine,

Budijono, Nathaniel,

Nami, Babak,

Sizova, Olga,

Kantautas, Kristin,

Chan, Katherine S,

Climie, Ryan,

Rojas Echenique, Jose I,

Ubhi, Tajinder,

Granda Farias, Adrian,

Wang, Zi Yang,

Lu, Xueibing,

Lin, Kevin,

Ji, Fenghu,

Soste, Martin,

Boone, Charles,

Wang, Wen,

Roth, Frederick P,

Lawson, Keith A,

Lim, Julianne,

Rohde, Thomas,

Brown, Kevin R,

Sartori Rodrigues, Maria,

Birkadze, Saba,

Drazic, Adrian,

Nixon, Allison,

Myers, Chad L,

Wei, Jiarun,

Cravatt, Benjamin F,

Roth, Amy F,

Bader, Gary D,

Turowec, Jacob,

Lee, Se

2025

Overview

We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ~90,000 genetic interactions, including thousands of extreme synthetic lethal and genetic suppression interactions. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes, pathways, biological processes, and cellular compartments. Comparative analyses showed that general principles of genetic networks are conserved from yeast to human cells. A genetic interaction network mapped in a single genetic background complements the DepMap gene co-essentiality network, recapitulating many of the same biological connections and also capturing unique functional information to reveal roles of uncharacterized genes and molecular determinants of specific cancer cell line genetic dependencies.

Share this book

Add to My Shelf

Publisher

Cold Spring Harbor Laboratory

Subject

Systems Biology