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Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ
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Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ
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Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ
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Paper
Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ
2023
Overview
Both viruses and bacteria produce pathogen associated molecular patterns that may affect microbial pathogenesis and anti-microbial responses. Additionally, bacteria produce metabolites while viruses could change metabolic profiles of the infected cells. Here, we used an unbiased metabolomics approach to profile metabolites in spleens and blood of Murine Leukemia Virus-infected mice monocolonized with Lactobacillus murinus to show that viral infection significantly changes the metabolite profile of monocolonized mice. We hypothesize that these changes could contribute to viral pathogenesis or to the host response against the virus and thus, open a new avenue for future investigations.Competing Interest StatementThe authors have declared no competing interest.
Publisher
Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
Subject
