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Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment
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Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment
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Journal Article
Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment
2023
Overview
Bacterial vaginosis (BV), a common syndrome characterized by
-deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote microbiota dominance by
instead of
, which has more beneficial health associations. Strategies to promote
and inhibit
are thus needed. We show that oleic acid (OA) and similar long-chain fatty acids simultaneously inhibit
and enhance
growth. These phenotypes require OA-inducible genes conserved in
and related species, including an oleate hydratase (
) and putative fatty acid efflux pump (
). FarE mediates OA resistance, while OhyA is robustly active in the human vaginal microbiota and sequesters OA in a derivative form that only
-harboring organisms can exploit. Finally, OA promotes
dominance more effectively than antibiotics in an
model of BV, suggesting a novel approach for treatment.
