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Therapeutic innovation in adult-onset Still’s disease (and other rare inflammatory disorders): how to secure evidence-based medicine?
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Therapeutic innovation in adult-onset Still’s disease (and other rare inflammatory disorders): how to secure evidence-based medicine?
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Journal Article
Therapeutic innovation in adult-onset Still’s disease (and other rare inflammatory disorders): how to secure evidence-based medicine?
2018
Overview
[...]this study represents a proof-of-concept suggesting that IL-18 inhibition could be a therapeutic option in this systemic inflammatory disease, with a reasonably acceptable safety profile. An example may be found within another inflammatory disease, giant cell arteritis (GCA). Since decades, physicians are in search of steroid-sparing agents and also new drugs for refractory forms of GCA. [...]we should reconcile medical and economical necessities, in order to benefit from therapeutic innovation without overlooking the lessons from the past. [...]we should combine efforts at national and international levels to develop independent institutional research in AOSD and better apprehend this multifaceted disease.
Publisher
Elsevier Limited
