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Factors associated with testing positive for syphilis among MSM who present as sexual contacts of syphilis from a clinic-based population
by
Pickering, Alice
, Trotman, Daniel
, Williams, Deborah
, Richardson, Daniel
, Fitzpatrick, Colin
, Nichols, Kayleigh
, Buss, Zoe
in
Adult
/ Ambulatory Care Facilities - statistics & numerical data
/ Anti-Infective Agents - therapeutic use
/ Antibiotics
/ Antimicrobial agents
/ Contact Tracing - statistics & numerical data
/ Cross-Sectional Studies
/ Drug resistance
/ Epidemiology
/ Homosexuality, Male - statistics & numerical data
/ Humans
/ Male
/ men
/ Middle Aged
/ Penicillin
/ penicillins
/ Serology
/ Sexual health
/ sexual partners
/ Syphilis
/ Syphilis - diagnosis
/ Syphilis - drug therapy
2022
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Factors associated with testing positive for syphilis among MSM who present as sexual contacts of syphilis from a clinic-based population
by
Pickering, Alice
, Trotman, Daniel
, Williams, Deborah
, Richardson, Daniel
, Fitzpatrick, Colin
, Nichols, Kayleigh
, Buss, Zoe
in
Adult
/ Ambulatory Care Facilities - statistics & numerical data
/ Anti-Infective Agents - therapeutic use
/ Antibiotics
/ Antimicrobial agents
/ Contact Tracing - statistics & numerical data
/ Cross-Sectional Studies
/ Drug resistance
/ Epidemiology
/ Homosexuality, Male - statistics & numerical data
/ Humans
/ Male
/ men
/ Middle Aged
/ Penicillin
/ penicillins
/ Serology
/ Sexual health
/ sexual partners
/ Syphilis
/ Syphilis - diagnosis
/ Syphilis - drug therapy
2022
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Factors associated with testing positive for syphilis among MSM who present as sexual contacts of syphilis from a clinic-based population
by
Pickering, Alice
, Trotman, Daniel
, Williams, Deborah
, Richardson, Daniel
, Fitzpatrick, Colin
, Nichols, Kayleigh
, Buss, Zoe
in
Adult
/ Ambulatory Care Facilities - statistics & numerical data
/ Anti-Infective Agents - therapeutic use
/ Antibiotics
/ Antimicrobial agents
/ Contact Tracing - statistics & numerical data
/ Cross-Sectional Studies
/ Drug resistance
/ Epidemiology
/ Homosexuality, Male - statistics & numerical data
/ Humans
/ Male
/ men
/ Middle Aged
/ Penicillin
/ penicillins
/ Serology
/ Sexual health
/ sexual partners
/ Syphilis
/ Syphilis - diagnosis
/ Syphilis - drug therapy
2022
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Factors associated with testing positive for syphilis among MSM who present as sexual contacts of syphilis from a clinic-based population
Journal Article
Factors associated with testing positive for syphilis among MSM who present as sexual contacts of syphilis from a clinic-based population
2022
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Overview
ObjectivesThere has been a significant increase in syphilis in men who have sex with men (MSM) in the UK over the past 20 years. Partner notification strategies have increased the number of MSM attending STI clinics as sexual contacts of syphilis. Current guidelines suggest testing and consideration of presumptive antimicrobial treatment. Syphilis treatment with benzathine penicillin requires clinic resources, is painful and is associated with complications. It is important we consider strategies to rationalise presumptive antimicrobial use and promote antimicrobial stewardship.MethodsWe aimed to determine if there are any factors associated with having syphilis among MSM attending as sexual contacts of syphilis in a cross-sectional study. We examined the clinical records of MSM attending as sexual contacts of syphilis from January to December 2019.ResultsOf the 6613 MSM who attended for STI testing, 142 of 6613 (2.1%) presented as sexual contacts of syphilis. The median age was 40 years (IQR=31–51), 43 of 142 (30%) were HIV positive, 38 of 142 (27%) had been diagnosed and treated for syphilis in the past, and 11 of 142 (8%) presented with symptoms (possible lesions of primary or secondary syphilis). Thirteen (9%, 95% CI=4.4 to 13.9) tested positive for syphilis on the day of presentation. MSM who were symptomatic (genital ulcer or body rash), HIV positive or had a history of syphilis were significantly more likely to test positive for syphilis (OR=51.88, 95% CI: 3.01 to 893.14, p=0.007).ConclusionsWe have shown that in our clinic-based population of MSM who presented as sexual contacts of syphilis, the factors associated with testing positive for syphilis were: having HIV, having a history of syphilis or presenting with symptoms (possible lesions of primary or secondary syphilis). These factors could be used to rationalise antibiotic treatment among MSM presenting as sexual contacts of syphilis. Further research is needed to validate this finding in other populations of MSM and people affected by syphilis.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD
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