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Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids
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Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids
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Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids
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Journal Article
Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids
1997
Overview
A crossbreed dog with a history of a chronic progressive tetra-paresis had an insulinoma-related peripheral polyneuropathy. Frequent feeding and treatment with corticosteroids resulted in recovery from a non-ambulatory to an almost completely normal clinical state, despite the persistence of hypoglycaemia and hyperinsulinism. After euthanasia for uncontrollable seizures, the presence of a beta-cell carcinoma of the pancreas and extensive axonal degeneration of the peripheral nerves was confirmed by histopathological examination. These findings may indicate an immune-mediated pathogenesis for insulinoma-related peripheral polyneuropathy.
Publisher
BMJ Publishing Group Limited,Blackwell Publishing Ltd
Subject
/ Antineoplastic Agents, Hormonal
/ Antineoplastic Agents, Hormonal - therapeutic use
/ Dogs
/ etiology
/ Male
/ Pancreatic Neoplasms - complications
/ Pancreatic Neoplasms - therapy
/ Pancreatic Neoplasms - veterinary
/ Peripheral Nervous System Diseases
/ Peripheral Nervous System Diseases - etiology
/ Peripheral Nervous System Diseases - veterinary
/ Prednisolone - therapeutic use
/ therapy
