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Somatostatin and adrenocorticotrophic hormone like immunoreactivity in small cell carcinoma of the lung

by Rèbel, A , Chretien, M F , Pouplard-Barthelaix, A , Dubois, M P , Simard, C

in Adrenocorticotropic Hormone - analysis / Biological and medical sciences / Carcinoma, Small Cell - analysis / Carcinoma, Small Cell - diagnosis / Fluorescent Antibody Technique / Hormones, Ectopic - analysis / Humans / Lung Neoplasms - analysis / Lung Neoplasms - diagnosis / Medical sciences / Pneumology / Somatostatin - analysis / Tumors of the respiratory system and mediastinum

1986

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Somatostatin and adrenocorticotrophic hormone like immunoreactivity in small cell carcinoma of the lung

by Rèbel, A , Chretien, M F , Pouplard-Barthelaix, A , Dubois, M P , Simard, C

1986

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Somatostatin and adrenocorticotrophic hormone like immunoreactivity in small cell carcinoma of the lung

by Rèbel, A , Chretien, M F , Pouplard-Barthelaix, A , Dubois, M P , Simard, C

1986

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Journal Article

Somatostatin and adrenocorticotrophic hormone like immunoreactivity in small cell carcinoma of the lung

Rèbel, A,

Chretien, M F,

Pouplard-Barthelaix, A,

Dubois, M P,

Simard, C

1986

Overview

The immunocytological detection of adrenocorticotrophic hormone (ACTH) and somatotropin release inhibitor factor (SRIF) like immunoreactivity was carried out on tumour cells from bronchial brush smears in 39 cases of lung tumours. Results obtained were compared with the cytological and histological diagnosis and confirmed the high incidence of ACTH synthesis by malignant bronchial carcinoma cells: the same phenomenon also seems to occur for somatostatin. The concomitant detection of ACTH and SRIF like immunoreactivity seems to be highly suggestive of small cell carcinoma and indicates that the immunocytological detection of hormones carried out at the same time as cytological examination can improve the accuracy of the diagnosis.

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Publisher

BMJ Publishing Group Ltd and Association of Clinical Pathologists,BMJ,BMJ Publishing Group LTD

Subject

Adrenocorticotropic Hormone - analysis

/ Biological and medical sciences

/ Carcinoma, Small Cell - analysis

/ Carcinoma, Small Cell - diagnosis

/ Fluorescent Antibody Technique

/ Hormones, Ectopic - analysis

/ Humans