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Enhanced Expression of dltABCD Is Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate of Staphylococcus aureus
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Enhanced Expression of dltABCD Is Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate of Staphylococcus aureus
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Enhanced Expression of dltABCD Is Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate of Staphylococcus aureus
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Journal Article
Enhanced Expression of dltABCD Is Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate of Staphylococcus aureus
2009
Overview
Using isogenic clinical bloodstream Staphylococcus aureus strains from a patient with relapsing endocarditis, we investigated the transcriptional profiles of the mprF and dlt genes in the context of cell-surface charge and daptomycin nonsusceptibility. As in prior studies, a point mutation within mprF was observed in the daptomycin-nonsusceptible strain. However, neither the transcriptional profile of mprF nor the membrane phospholipid analyses were compatible with the anticipated mprF gain-in-function phenotype. In contrast, we demonstrated enhanced dlt expression coincident with increased positive surface charge and reduced daptomycin binding
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
Anti-Bacterial Agents - metabolism
/ Anti-Bacterial Agents - pharmacology
/ BACTERIA
/ Bacterial Proteins - biosynthesis
/ Bacterial Proteins - genetics
/ Biological and medical sciences
/ Cubism
/ Endocarditis, Bacterial - microbiology
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Operons
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - drug effects
