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Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England

by Sakellariou, Giorgos K , Croden, Fiona , McArdle, Anne , Owens, Daniel J , Sinclair, Melanie , Tang, Jonathan , Lawton, Clare , Fenech, Manuel , Earl, Kate E , Dye, Louise , Close, Graeme L , Fraser, William D , Beadsworth, Michael B J , Miller, Alastair

in Case-Control Studies / Chronic fatigue syndrome / Cohort analysis / Dietary supplements / Disease / Encephalomyelitis - epidemiology / England / Fatigue / Fatigue Syndrome, Chronic - epidemiology / Health services / Humans / Metabolites / Muscle function / Musculoskeletal system / Nutrition and Metabolism / Vitamin D / Vitamin D Deficiency - epidemiology / Vitamin deficiency

2017

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Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England

2017

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Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England

2017

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Journal Article

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England

Sakellariou, Giorgos K,

Croden, Fiona,

McArdle, Anne,

Owens, Daniel J,

Sinclair, Melanie,

Tang, Jonathan,

Lawton, Clare,

Fenech, Manuel,

Earl, Kate E,

Dye, Louise,

Close, Graeme L,

Fraser, William D,

Beadsworth, Michael B J,

Miller, Alastair

2017

Overview

ObjectiveSevere vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with altered circulating vitamin D metabolites.DesignCohort study.SettingUK university hospital, recruiting from April 2014 to April 2015.ParticipantsNinety-two patients with CFS/ME and 94 age-matched healthy controls (HCs).Main outcome measuresThe presence of a significant association between CFS/ME, fatigue and vitamin D measures.ResultsNo evidence of a deficiency in serum total 25(OH) vitamin D (25(OH)D2 and 25(OH)D3 metabolites) was evident in individuals with CFS/ME. Liquid chromatography tandem mass spectrometry (LC–MS/MS) analysis revealed that total 25(OH)D was significantly higher (p=0.001) in serum of patients with CFS/ME compared with HCs (60.2 and 47.3 nmol/L, respectively). Analysis of food/supplement diaries with WinDiets revealed that the higher total 25(OH) vitamin D concentrations observed in the CFS/ME group were associated with increased vitamin D intake through use of supplements compared with the control group. Analysis of Chalder Fatigue Questionnaire data revealed no association between perceived fatigue and vitamin D levels.ConclusionsLow serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS/ME.

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Publisher

BMJ Publishing Group LTD,BMJ Publishing Group

Subject

Case-Control Studies

/ Chronic fatigue syndrome

/ Cohort analysis

/ Dietary supplements

/ Disease

/ Encephalomyelitis - epidemiology

/ England