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Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients
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Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients
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Journal Article
Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients
2011
Overview
Purpose
The pathogenic role of angiotensin-converting enzyme (ACE) inhibition in hypertensive patients regarding endothelial progenitor-cell (EPC) function is still poorly understood. The aim of the study was to evaluate EPC number, function, and relationship to carotid intima media thickness (IMT) progression.
Methods
We studied 36 newly diagnosed mildly hypertensive patients free of cardiovascular disease and related risk factors without prior or concurrent therapy with ACE inhibitors. Patients were randomized to receive enalapril 20 mg/day (
n
= 18) or zofenopril 30 mg/day (
n
= 18). EPC number and migrating capacity, plasma nitrite and nitrate (NOx), and isoprostane concentrations were evaluated. Carotid IMT was determined by ultrasonography at baseline and after 1 and 5 years of follow-up.
Results
EPC number increased during the follow-up, with no statistical differences between treatment groups. There was an inverse correlation between circulating EPCs and IMT increase over time. Plasma NOx decreased during the study without evident differences between treatment groups. Isoprostanes decreased more markedly in zofenopril-treated patients. Multiple linear regression model demonstrated that carotid IMT was significantly inversely correlated with EPC but not with migratory cells after adjusting for confounders.
Conclusions
The study demonstrated that EPC levels increased during the follow-up in both groups of newly diagnosed hypertensive patients treated with ACE inhibitors. These drugs prevented progression of vascular damage, with an inverse correlation between circulating EPC levels and IMT values.
Publisher
Springer-Verlag,Springer,Springer Nature B.V,Springer Verlag
Subject
/ Adult
/ Angiotensin-Converting Enzyme Inhibitors - administration & dosage
/ Angiotensin-Converting Enzyme Inhibitors - therapeutic use
/ Arterial hypertension. Arterial hypotension
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Captopril - administration & dosage
/ Captopril - analogs & derivatives
/ Carotid Arteries - diagnostic imaging
/ Carotid Arteries - pathology
/ Cell Movement - drug effects
/ Enalapril - administration & dosage
/ Endothelial Cells - cytology
/ Endothelial Cells - drug effects
/ Humans
/ Pharmacology. Drug treatments
