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Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone
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Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone
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Journal Article
Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone
1976
Overview
An analysis of the factors that influence the increase in plasma immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) concentration in chronic renal failure showed that: (a) the increase correlated with the increase in serum creatinine concentrations; (b) beta-MSH was not cleared from the plasma by haemodialysis; (c) beta-MSH concentrations increased with length of time on dialysis and increased further after bilateral nephrectomy but there was no further increase with time; (d) beta-MSH levels decreased to normal after renal transplantation; and (e) beta-MSH was excreted in urine only when plasma levels rose to well above those of chronic renal failure (in Nelson's syndrome). These findings suggest that the kidney regulated plasma beta-MSH by a non-excretory mechanism and is the major site of beta-MSH metabolism.
Publisher
British Medical Journal Publishing Group,British Medical Association,BMJ Publishing Group LTD
Subject
/ Dialysis
/ Hormones
/ Humans
/ Kidney Failure, Chronic - physiopathology
/ Kidney Failure, Chronic - therapy
/ Kidneys
/ Melanocyte-Stimulating Hormones - blood
/ Melanocyte-Stimulating Hormones - immunology
/ Melanocyte-Stimulating Hormones - metabolism
/ Melanocyte-Stimulating Hormones - urine
/ Urine
