Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

by McKay, Sean , Kandasamy, Jothy , Hardingham, Giles E. , Tzioras, Makis , Hernandez, Madison , Stevenson, Anna J. , Karadottir, Ragnhildur Thora , Brennan, Paul M. , King, Declan , Sokol, Drahoslav , Borella, Julia , McColl, Barry W. , Barrington, Jack , Holloway, Rebecca K. , Baxter, Paul , Latta, Clare , Varga, Balazs , Smith, Colin , Daniels, Michael J.D. , Davies, Caitlin , Miron, Veronique E. , Henstridge, Christopher M. , Spires-Jones, Tara L. , Popovic, Karla , Drinkwater, Elizabeth , Tulloch, Jane

in Neuroscience

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

in Neuroscience

2023

Confirm

Do you wish to request the book?

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

in Neuroscience

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Paper

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

McKay, Sean,

Kandasamy, Jothy,

Hardingham, Giles E.,

Tzioras, Makis,

Hernandez, Madison,

Stevenson, Anna J.,

Karadottir, Ragnhildur Thora,

Brennan, Paul M.,

King, Declan,

Sokol, Drahoslav,

Borella, Julia,

McColl, Barry W.,

Barrington, Jack,

Holloway, Rebecca K.,

Baxter, Paul,

Latta, Clare,

Varga, Balazs,

Smith, Colin,

Daniels, Michael J.D.,

Davies, Caitlin,

Miron, Veronique E.,

Henstridge, Christopher M.,

Spires-Jones, Tara L.,

Popovic, Karla,

Drinkwater, Elizabeth,

Tulloch, Jane

2023

Overview

Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence for any glial involvement in synapse removal in human AD remains to be established. Here we observe astrocytes and microglia from human brains contain greater amounts of synaptic protein in AD compared to non-disease controls, and that proximity to amyloid-β plaques and the APOE4 risk gene exacerbate this effect. In culture, mouse and human astrocytes and primary mouse and human microglia phagocytose AD patient-derived synapses more than synapses from controls. Inhibiting MFG-E8 function rescued the elevated engulfment of AD synapses by astrocytes and microglia without affecting control synapse uptake. Thus, AD promotes increased synapse ingestion by human glial cells via an MFG-E8 opsonophagocytic mechanism with potential for targeted therapeutic manipulation. Glial cells ingest synapses in Alzheimer’s disease and antibody treatment reduces this ingestion in cultured human cells.

Share this book

Add to My Shelf

Publisher

Cold Spring Harbor Laboratory

Subject

Neuroscience