Journal Article

Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up

Whynes, D K, Hardcastle, J D, Scholefield, J H, Mangham, C M, Moss, S M

2012

Overview

BackgroundThree large randomised trials have shown that screening for colorectal cancer (CRC) using the faecal occult blood test (FOBt) can reduce the mortality from this disease. The largest of these trials, conducted in Nottingham since 1981, randomised 152 850 individuals between the ages of 45 and 74 years to an intervention arm receiving biennial Haemoccult (FOB) test kit or to a control arm. In 2006, the National Bowel Cancer Screening Programme was launched in England using the FOBt, with the expectation that it will reduce CRC mortality.AimsTo compare the CRC mortality and incidence in the intervention arm with the control arm after long-term follow-up.MethodsThe 152 850 randomised individuals were followed up through local health records and central flagging (Office for National Statistics).ResultsAt a median follow-up of 19.5 years there was a 13% reduction in CRC mortality (95% CI 3% to 22%) in the intervention arm despite an uptake at first invitation of approximately 57%. The CRC mortality reduction in those accepting the first screening test, adjusted for the rate of non-compliers, was 18%. There was no significant difference in mortality from causes other than CRC between the intervention and control arms. Despite removing 615 adenomas >10 mm in size from the intervention arm, there was no significant difference in CRC incidence between the two arms.ConclusionsAlthough the reduction in CRC mortality was sustained, further follow-up of the screened population has not shown a significant reduction in the CRC incidence. Moreover, despite the removal of many large adenomas there was no reduction in the incidence of invasive cancer which was independent of sex and site of the tumour.

• Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology,BMJ Publishing Group,BMJ Publishing Group LTD
• Subject: abdominal surgery / adenoma / Adenoma - diagnosis / Adenoma - mortality / Adenoma - prevention & control / Aged / Biological and medical sciences / cancer susceptibility / clinical trials / colon carcinogenesis / colonoscopy / Colorectal cancer / colorectal cancer screening / Colorectal Neoplasms - diagnosis / Colorectal Neoplasms - mortality / Colorectal Neoplasms - prevention & control / Compliance / Early Detection of Cancer - methods / Faecal occult blood testing / Follow-Up Studies / Gastroenterology. Liver. Pancreas. Abdomen / Hospitals / Humans / Incidence / Intention to Treat Analysis / Mass Screening / Medical sciences / Medical screening / Middle Aged / Mortality / Occult Blood / Occult sciences / Population / screening / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Survival Rate / Tumors