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Antihyperglycemic and hypolipidemic activity of methanolic extract of Amaranthus viridis leaves in experimental diabetes
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Antihyperglycemic and hypolipidemic activity of methanolic extract of Amaranthus viridis leaves in experimental diabetes
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Journal Article
Antihyperglycemic and hypolipidemic activity of methanolic extract of Amaranthus viridis leaves in experimental diabetes
2011
Overview
To investigate the antihyperglycemic and hypolipidemic effects of
methanolic extract of leaves of Amaranthus viridis (MEAV) in normal
and Streptozotocin (STZ) induced diabetic rats. The anti-hyperglycemic
and hypolipidemic activity of methanolic extract of leaves of
Amaranthus viridis was evaluated by using normal and STZ induced
diabetic rats at dose of 200 mg/kg and 400 mg/kg by mouth per day for
21 days. Blood glucose levels and body weight was monitored at specific
intervals, and different biochemical parameters, serum cholesterol,
serum triglyceride, high density lipoprotein, low density lipoprotein,
very low density lipoprotein were also assessed in the experimental
animals. Histology of pancreas was performed. The statistical data
indicated a significant increase in the body weight, decrease in the
blood glucose, total cholesterol and serum triglycerides after
treatment with MEAV. High density lipoprotein (HDL) cholesterol level
was significantly increased when treated with extract. Histologically,
focal necrosis was observed in the diabetic rat pancreas; however, was
less obvious in treated groups. The MEAV has beneficial effects in
reducing the elevated blood glucose level and body weight changes, and
improves the lipid profile of STZ induced rats.
Publisher
Medknow Publications on behalf of Indian Pharmacological Society,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications
