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Improved opioid prescribing in primary care: protocol for a cluster randomised pragmatic trial
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Improved opioid prescribing in primary care: protocol for a cluster randomised pragmatic trial
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Improved opioid prescribing in primary care: protocol for a cluster randomised pragmatic trial
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Journal Article
Improved opioid prescribing in primary care: protocol for a cluster randomised pragmatic trial
2025
Overview
IntroductionOpioid analgesic medications play a critical role in pain management but are associated with significant risks, including addiction. General practitioners in primary care account for a substantial proportion of opioid prescriptions, and prescribing practices may not always fully align with clinical guidelines. Given the limited evidence supporting long-term opioid use for chronic non-cancer pain, there is a pressing need for interventions that promote safer, guideline-concordant prescribing. The Smarta Val (Smart Choices) trial will evaluate whether a new multicomponent intervention, comprising an educational seminar, written materials and feedback on prescribing over 12 months, can improve opioid prescribing practices in primary care.Methods and analysisThis cluster randomised pragmatic trial will assess changes in opioid prescribing across primary healthcare centres (PHCCs) in Stockholm, Sweden. Consenting PHCCs will be randomised 1:1 to either the intervention group, receiving the multicomponent intervention, or the active control group, receiving a leaflet on prescribing recommendations. A sample size of 24 PHCCs per group is required to detect differences in opioid prescribing between groups. A third group of non-randomised observational reference PHCCs will be included to provide contextual information on prescribing practices during the study period. Data sources include regional healthcare databases, baseline and 12-month follow-up questionnaires, and an intervention delivery form. The primary outcome is the change in prescription of opioids at 12 months. Secondary outcomes are the change in prescription of opioids at 24 months and the change in the specific opioid substances prescribed at 12 months.Ethics and disseminationThe study has been approved by the Swedish Ethical Review Authority (Dnr 2021-06739-01). Participation in the study requires informed consent from PHCC managers in the intervention and active control groups. Results will be disseminated through international peer-reviewed journals and conference presentations.Trial registration numberNCT05577026.
Publisher
British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
Analgesics, Opioid - therapeutic use
/ Clinical practice guidelines
/ Drug Prescriptions - statistics & numerical data
/ Feedback
/ General practice / Family practice
/ Humans
/ Managers
/ Patients
/ Practice Patterns, Physicians' - standards
/ Practice Patterns, Physicians' - statistics & numerical data
/ Pragmatic Clinical Trials as Topic
/ Protocol
/ Randomized Controlled Trials as Topic
/ Seminars
/ Sweden
/ Trends
