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Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

by Nicolle, Michael W , Pascuzzi, Robert M , Wulf, Charlie , Soloway, Aimee , Evoli, Amelia , Jiwa, Theresa , Massey, Janice M , Traynor, Bryan J , Benatar, Michael , Howard, James F , Siddiqi, Zaeem , Dimachkie, Mazen M , Marino, Mariapaola , Kaminski, Henry J , Chopra, Manisha , Freimer, Miriam , Mezei, Michelle M , Lipscomb, Bernadette , Pestronk, Alan , Koopman, Wilma J , Richman, David P , Maestri, Michelanglo , Bartoccion, Emanuela , Florence, Julaine , Corse, Andrea , Wolfe, Gil I , Pasnoor, Mamatha , Oger, Joel , Kissel, John T , Muppidi, Srikanth , Green, Joshua D , Chaudhry, Vinay , McVey, April , Sanders, Donald B , Drachman, Daniel B , Blackmore, Derrick , Rowin, Julie , Barohn, Richard J , Provenzano, Carlo , Ricciardi, Roberta

in Age / Antibodies / Autoantibodies / Autoimmune diseases / Cohort analysis / Deoxyribonucleic acid / DNA / Epidemiology / Family medical history / Genetic testing / genetics / Humans / Literature reviews / Myasthenia gravis / Myasthenia Gravis - epidemiology / Myasthenia Gravis - genetics / neurogenetics / neurology / neuromuscular disease / North America - epidemiology / Patients / Receptors, Cholinergic / Retrospective Studies / Rheumatoid arthritis / Thyroid diseases

2020

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Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

2020

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Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

2020

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Journal Article

Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

Nicolle, Michael W,

Pascuzzi, Robert M,

Wulf, Charlie,

Soloway, Aimee,

Evoli, Amelia,

Jiwa, Theresa,

Massey, Janice M,

Traynor, Bryan J,

Benatar, Michael,

Howard, James F,

Siddiqi, Zaeem,

Dimachkie, Mazen M,

Marino, Mariapaola,

Kaminski, Henry J,

Chopra, Manisha,

Freimer, Miriam,

Mezei, Michelle M,

Lipscomb, Bernadette,

Pestronk, Alan,

Koopman, Wilma J,

Richman, David P,

Maestri, Michelanglo,

Bartoccion, Emanuela,

Florence, Julaine,

Corse, Andrea,

Wolfe, Gil I,

Pasnoor, Mamatha,

Oger, Joel,

Kissel, John T,

Muppidi, Srikanth,

Green, Joshua D,

Chaudhry, Vinay,

McVey, April,

Sanders, Donald B,

Drachman, Daniel B,

Blackmore, Derrick,

Rowin, Julie,

Barohn, Richard J,

Provenzano, Carlo,

Ricciardi, Roberta

2020

Overview

ObjectivesTo approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.DesignRetrospective cohort study.SettingClinics across North America.ParticipantsThe study included 1032 patients diagnosed with acetylcholine receptor antibody (AChR)-positive myasthenia gravis.MethodsPhenotype information of 1032 patients diagnosed with AChR-positive myasthenia gravis was obtained from clinics at 14 centres across North America between January 2010 and January 2011. A critical review of the epidemiological literature on the familial rate of myasthenia gravis was also performed.ResultsAmong 1032 patients, 58 (5.6%) reported a family history of myasthenia gravis. A history of autoimmune diseases was present in 26.6% of patients and in 28.4% of their family members.DiscussionThe familial rate of myasthenia gravis was higher than would be expected for a sporadic disease. Furthermore, a high proportion of patients had a personal or family history of autoimmune disease. Taken together, these findings suggest a genetic contribution to the pathogenesis of myasthenia gravis.

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Publisher

British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group

Subject

Age

/ Antibodies

/ Autoantibodies

/ Autoimmune diseases

/ Cohort analysis

/ Deoxyribonucleic acid

/ DNA