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Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report
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Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report
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Journal Article
Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report
2018
Overview
Objective
To report a case of successful allogeneic grafting of mesenchymal dental pulp stem cells (DPSCs) as preliminary findings in a patient with periodontal disease enrolled into clinical trial ISRCTN12831118.
Methods
Mesenchymal stem cells from the dental pulp of a deciduous tooth from a 7-year-old donor were separated from the pulp chamber and processed via enzymatic digestion and centrifugation. DPSCs were passaged and cultured on a 35 × 13 mm culture dish in minimum essential medium-alpha, without supplementation. After reaching 80% confluency, 5 x 106 allogeneic DPSCs in 250 µl phosphate buffered saline were seeded onto a dry scaffold of lyophilized collagen-polyvinylpyrrolidone sponge placed in the left lower premolar area of a 61-year-old patient with periodontal disease. Surgical access to the lower premolar area was achieved using the flap technique.
Results
At 3 and 6 months following allogeneic graft, the patient showed no sign of rejection and exhibited decreases in tooth mobility, periodontal pocket depth and bone defect area. Bone mineral density had increased at the graft site.
Conclusions
Regenerative periodontal therapy using DPSCs of allogeneic origin may be a promising treatment for periodontal disease-induced bone defects.
Publisher
SAGE Publications,Sage Publications Ltd,SAGE Publishing
Subject
/ Child
/ Cone-Beam Computed Tomography
/ Dental Pulp - diagnostic imaging
/ Dental Pulp - transplantation
/ Humans
/ Male
/ Mesenchymal Stem Cell Transplantation - methods
/ Periodontal Diseases - complications
/ Periodontal Diseases - diagnostic imaging
/ Periodontal Diseases - physiopathology
/ Periodontal Diseases - surgery
/ Tooth Loss - diagnostic imaging
