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Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons
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Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons
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Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons
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Journal Article
Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons
2017
Overview
Limited by the tiny structure of axons,the effects of these axonal hyperpolarizing inputs on neuronal activity have not been directly elucidated.Here,we imitated these processes by simultaneously recording the activities of the somas and proximal axons of cortical pyramidal neurons.We found that spikes and subthreshold potentials propagate between somas and axons with high fidelity.Furthermore,inhibitory inputs on axons have opposite effects on neuronal activity according to their temporal integration with upstream signals.Concurrent with somatic depolarization,inhibitory inputs on axons decrease neuronal excitability and impede spike generation.In addition,following action potentials,inhibitory inputs on an axon increase neuronal spike capacity and improve spike precision.These results indicate that inhibitory inputs on proximal axons have dual regulatory functions in neuronal activity（suppression or facilitation）according to neuronal network patterns.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Department of Pathophysiology, Bengbu Medical College, Bengbu, Anhui Province, China,Department of General Surgery, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, China%Department of Pathophysiology, Bengbu Medical College, Bengbu, Anhui Province, China%Department of Physiology, Bengbu Medical College, Bengbu, Anhui Province, China%Guangdong-Hongkong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration, Ministry of Education, Jinan University, Guangzhou, Guangdong Province, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
