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P132 Prevalence of iron deficiency in patients with inflammatory bowel disease at University Hospitals Southampton
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P132 Prevalence of iron deficiency in patients with inflammatory bowel disease at University Hospitals Southampton
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Journal Article
P132 Prevalence of iron deficiency in patients with inflammatory bowel disease at University Hospitals Southampton
2024
Overview
IntroductionIron deficiency anaemia (IDA) and iron deficiency without anaemia (IDWA) are associated with worse quality of life in patients with inflammatory bowel disease (IBD). The prevalence of iron deficiency in IBD varies greatly in recent studies. We aimed to identify the prevalence of iron deficiency in patients with IBD at our institution.MethodsPatients with diagnoses of IBD were identified by searching electronic records at UHS, with confirmation by manual chart review by a clinician. Patients with a confirmed diagnosis of IBD within the city and in contact with the UHS IBD team in 2022 were included. Pathology results were extracted for 12 months over 2022 for haemoglobin, ferritin, transferrin saturation, CRP and calprotectin. Anaemia was defined as Hb <130 g/L in males and <120 g/L in females. Absolute iron deficiency was defined as ferritin <11µg/L in females and <24µg/L in males. Iron deficiency in inflammation was defined as ferritin above the previous cuts-off and <100µg/L with CRP > 8mg/L within ten days or calprotectin >250mcg/L within 60 days. For diagnosis of iron deficiency anaemia (IDA) or iron deficiency without anaemia (IDWA), ferritin was tested within 30 days of Hb. Statistical comparisons were made using Chi-squared.Results694 patients met the inclusion criteria and were tested for ferritin and Hb within 30 days of each other. 307 (44.24%) were male. 331 (47.69%) had a diagnosis of Crohn’s disease, 328 (47.26%) had ulcerative colitis (UC), and 35 (5.04%) had IBD unclassified. Table 1 shows the detected prevalence of iron deficiency by diagnosis. 34 patients had tests showing IDWA and IDA occurring at different times over the 12 months. Women had a significantly higher IDWA prevalence than men 25.58% v 18.89% (p = 0.045).Abstract P132 Table 1Number of patients with iron deficiency by diagnosis Diagnosis n IDA IDWA All iron deficiency Crohn’s 331 44 (13.29%) 77 (23.26%) 105 (31.72%) Ulcerative colitis 328 44 (13.41%) 72 (21.95%) 99 (30.18%) IBD Unclassified 35 5 (14.2%) 8 (22.86%) 12 (34.29%) p-value 0.987 0.922 0.834 There were no significant differences in the number of female patients with iron deficiency in ulcerative colitis v Crohn’s disease.Conclusions Unlike previous studies, there is a similar prevalence of iron deficiency in patients with Crohn’s disease and UC. Overall, nearly a third of patients with IBD were iron deficient, within the range of prevalence found in previous studies.
Publisher
BMJ Publishing Group Ltd and British Society of Gastroenterology,BMJ Publishing Group LTD
