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CircRNA: functions and properties of a novel potential biomarker for cancer

by Wu, Minghua , Xu, Zihao , Zhou, Hecheng , Feng, Ziyang , Meng, Shujuan , Li, Peiyao , Tang, Ying

in Analysis / Animals / Biological markers / Biomarker / Biomarkers / Biomarkers, Tumor / Biomedical and Life Sciences / Biomedicine / Biosynthesis / Cancer / Cancer Research / circRNA / Colorectal cancer / Diagnosis / Eukaryotic Cells - metabolism / Genes / Genetic aspects / Humans / Leukemia / Localization / Lung cancer / MicroRNA / microRNA sponge / MicroRNAs - genetics / Neoplasms - diagnosis / Neoplasms - genetics / Neoplasms - metabolism / Non-coding RNA / Oncology / Physiological aspects / Review / Reviews / RNA - genetics / RNA - metabolism / RNA Stability / RNA, Messenger - genetics / RNA, Neoplasm / RNA, Untranslated - genetics / RNA-Binding Proteins - metabolism / Rodents / Studies / Tumors / Tumour

2017

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CircRNA: functions and properties of a novel potential biomarker for cancer

by Wu, Minghua , Xu, Zihao , Zhou, Hecheng , Feng, Ziyang , Meng, Shujuan , Li, Peiyao , Tang, Ying

2017

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CircRNA: functions and properties of a novel potential biomarker for cancer

by Wu, Minghua , Xu, Zihao , Zhou, Hecheng , Feng, Ziyang , Meng, Shujuan , Li, Peiyao , Tang, Ying

2017

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Journal Article

CircRNA: functions and properties of a novel potential biomarker for cancer

Wu, Minghua,

Xu, Zihao,

Zhou, Hecheng,

Feng, Ziyang,

Meng, Shujuan,

Li, Peiyao,

Tang, Ying

2017

Overview

Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generation and function are not fully clear, recent research has shown that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours. This review summarizes some information about categories, biogenesis, functions at the molecular level, properties of circular RNAs and the possibility of circular RNAs as biomarkers in cancers.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ Animals

/ Biomedical and Life Sciences