Journal Article

Pembrolizumab-related systemic myositis involving ocular and hindneck muscles resembling myasthenic gravis: a case report

Kamo, Hikaru, Aoki, Nozomi, Kanai, Kazuaki, Hattori, Nobutaka, Yamashita, Yuri, Hatano, Taku, Kamiyama, Daiki, Shimo, Yasushi, Yokoyama, Kazumasa, Takanashi, Masashi

2019

Overview

Background Pembrolizumab is an immune-checkpoints inhibitor that enhances the immune response against cancer cells and therefore is useful for the treatment of several carcinomas. However, pembrolizumab sometimes perturbs the immune system resulting in various autoimmune neurological complications. In this situation, autoimmune myositis due to pembrolizumab is a rare but not-negligible complication. Here, we report two cases of autoimmune myositis due to pembrolizumab, with systemic myositis involving levator palpebrae superioris, extraocular and hindneck muscles. Case presentation Case 1 was a 78-year-old man with advanced urinary cancer referred to the neurological ward presenting with bilateral ptosis, restriction of eye movements, dropped head and weakness in the lower extremities after pembrolizumab administration. His blood examination showed elevated serum levels of creatine kinase with positive anti-PM-Scl 75 and anti-signal recognition particle antibodies. Needle electromyography and MRI suggested systemic inflammatory myopathy. There were no findings to indicate myocardial involvement on electrocardiogram or echocardiogram. Administration of intravenous methylprednisolone following plasma exchange ameliorated creatine kinase levels and inhibited the progression of clinical symptoms. Case 2 was a 72-year-old female with lung cancer and multiple metastasis, including lymph nodes and brain. She presented with back pain, right-sided ptosis, weakness of her neck extensors and flexors and elevated serum creatine kinase after receiving pembrolizumab. Although myositis specific autoantibodies were negative, needle electromyography and MRI suggested systemic inflammatory myopathy and muscle biopsy indicated necrotizing myopathy. There were no signs indicating heart dysfunction and her electrocardiogram was normal. Clinical symptoms and serum creatine kinase levels were ameliorated after the administration of intravenous methylprednisolone. Conclusions Both cases showed atypical extensive inflammatory myositis including levator palpebrae superioris, extraocular and hindneck muscles, resembling myasthenia gravis (MG), but they did not have MG-related antibodies. Edrophonium test was negative and showed no daily fluctuation. Two previously reported cases also presented with systemic necrotizing systemic myositis involving extraocular and facial muscles caused by pembrolizumab. Idiopathic inflammatory myositis evolving levator palpebrae superioris and ocular muscles is quite rare; however, myositis due to immune-checkpoint inhibitors may preferentially involve these muscles. This case report will alert physicians to the possibility of systemic inflammatory myopathy evolving levator palpebrae superioris, extraocular and hindneck muscles mimicking MG due to pembrolizumab.

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Antibodies / Autoantibodies / Autoimmunity / Back pain / Blepharoptosis / Cancer / Cancer cells / Cancer metastasis / Cancer treatment / Care and treatment / Case Report / Creatine / Creatine kinase / Diagnostic imaging / Dosage and administration / Electrocardiography / Glucocorticoids / ICPIs-related systemic myositis / Immune response / Immune system / Immune-related adverse events / Lung cancer / Medical research / Medicine / Medicine & Public Health / Methylprednisolone / Myasthenia gravis / Myositis / Necrotizing myositis / Neurochemistry / Neurology / Neuromuscular disorders and peripheral neurology / Neurosurgery / Ocular myositis / Pembrolizumab / Physicians