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6.12 Discovery of tc1; a marker of delayed recovery from concussion in children
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6.12 Discovery of tc1; a marker of delayed recovery from concussion in children
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Journal Article
6.12 Discovery of tc1; a marker of delayed recovery from concussion in children
2024
Overview
ObjectiveTo identify blood proteins differentially expressed in children with and without delayed recovery from concussion.DesignA single centre, prospective, longitudinal cohort study.SettingThe Royal Children’s Hospital (RCH), a paediatric tertiary care centre in Victoria, Australia.ParticipantsChildren aged 5 to 18 years who presented to the RCH Emergency Department within 48 hours of a concussion (n=40). Controls included children with upper body orthopaedic injury (n=7), and otherwise healthy children undergoing elective day surgery at the RCH (n=33).Interventions (or Assessment of Risk Factors)Delayed recovery from concussion, determined using the Post-Concussion Symptoms Inventory at two weeks post-injury.Outcome MeasuresRelative abundance, obtained using single window acquisition of all theoretical mass spectra (SWATH-MS), and absolute concentration, obtained using multiple reaction monitoring (MRM) and enzyme linked immunosorbent assay (ELISA), of differentially abundant proteins in children with and without delayed recovery from concussion.Main ResultsSix of the proteins differentially expressed in children with and without delayed recovery from concussion were selected for validation using a protocol comprising of a statistical and non-statistical component. Most notably, a support vector machine including one protein, TC1, (temporary codename pending patent protection) differentiated between children with and without delayed recovery from concussion with an accuracy of 81% [95% confidence interval 65 – 96%].ConclusionsTC1 has been identified as a marker of delayed recovery from concussion in children, which has the capacity to transform the way that delayed recovery is assessed and treated in a clinical setting.
Publisher
BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine,BMJ Publishing Group LTD
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