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Sperm chemotaxis is driven by the slope of the chemoattractant concentration field
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Paper
Sperm chemotaxis is driven by the slope of the chemoattractant concentration field
2020
Overview
Spermatozoa of marine invertebrates are attracted to their conspecific female gamete by diffusive molecules, called chemoattractants, released from the egg in-vestments in a process known as chemotaxis. The information from the egg chemoat-tractant concentration field is decoded into intracellular Ca2+ concentration ([Ca2+]i) changes that regulate the internal motors that shape the flagellum as it beats. By studying sea urchin species-specific differences in sperm chemoattractant-receptor characteristics we show that receptor density constrains the steepness of the chemo-attractant concentration gradient detectable by spermatozoa. Through analyzing dif-ferent chemoattractant gradient forms, we demonstrate for the first time that Strongy-locentrotus purpuratus sperm are chemotactic and this response is consistent with frequency entrainment of two coupled physiological oscillators: i) the stimulus func-tion and ii) the [Ca2+]i changes. We demonstrate that the slope of the chemoattractant gradients provides the coupling force between both oscillators, arising as a funda-mental requirement for sperm chemotaxis.
Publisher
Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
Subject
