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Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila
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Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila
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Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila
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Paper
Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila
2018
Overview
The mechanism by which apoptotic cells release signals that induce undamaged neighbor cells to proliferate and regenerate missing parts remains elusive. Oxidative stress originated by dying or damaged cells can be propagated to neighboring cells, which then promote regeneration. We investigated the nature of the stress sensing mechanism by which neighboring cells are recruited. We found that Drosophila apoptosis signal-regulating kinase 1 (Ask1) senses reactive oxygen species (ROS) differently in stressed dying cells and unstressed neighboring cells and this differential sensing is pivotal for tissue repair. In undamaged cells, this activity is attenuated, but not abolished, by Akt1 phosphorylation, which thus acts as a survival signal that results in the tolerable levels of p38 and JNK necessary for regeneration. These observations demonstrate that the non-autonomous activation of the ROS-sensing mechanism by Ask1 and Akt1 in neighboring unstressed cells. Collectively, these results provide the basis for understanding the molecular mechanism of communication between dying and living cells that triggers regeneration.
Publisher
Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
