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Immune Landscapes Predict Chemotherapy Resistance And Immunotherapy Response In Acute Myeloid Leukemia

by Sullivan, Amy H , Jayakumar Vadakekolathu , Altmann, Heidi , Liang, Yan , Warren, Sarah E , Minden, Mark D , Patel, Tasleema , Valk, Peter Jm , Cesano, Alessandra , Schmitz, Marc , Ibrahimova, Narmin , A Graham Pockley , Reeder, Stephen , Davidson-Moncada, Jan K , Church, Sarah E , Viboch, Elena J , Tasian, Sarah K , Dipersio, John F , Rutella, Sergio , Arruda, Andrea , Bornhauser, Martin , Hood, Tressa , Muth, John , Lowenberg, Bob , Rettig, Michael P

in Acute myeloid leukemia / Bone marrow / Chemoresistance / Chemotherapy / Gene expression / Immunology / Immunotherapy / Leukemia / Myeloid leukemia / γ-Interferon

2019

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Immune Landscapes Predict Chemotherapy Resistance And Immunotherapy Response In Acute Myeloid Leukemia

in Acute myeloid leukemia / Bone marrow / Chemoresistance / Chemotherapy / Gene expression / Immunology / Immunotherapy / Leukemia / Myeloid leukemia / γ-Interferon

2019

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Immune Landscapes Predict Chemotherapy Resistance And Immunotherapy Response In Acute Myeloid Leukemia

in Acute myeloid leukemia / Bone marrow / Chemoresistance / Chemotherapy / Gene expression / Immunology / Immunotherapy / Leukemia / Myeloid leukemia / γ-Interferon

2019

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Paper

Immune Landscapes Predict Chemotherapy Resistance And Immunotherapy Response In Acute Myeloid Leukemia

Sullivan, Amy H,

Jayakumar Vadakekolathu,

Altmann, Heidi,

Liang, Yan,

Warren, Sarah E,

Minden, Mark D,

Patel, Tasleema,

Valk, Peter Jm,

Cesano, Alessandra,

Schmitz, Marc,

Ibrahimova, Narmin,

A Graham Pockley,

Reeder, Stephen,

Davidson-Moncada, Jan K,

Church, Sarah E,

Viboch, Elena J,

Tasian, Sarah K,

Dipersio, John F,

Rutella, Sergio,

Arruda, Andrea,

Bornhauser, Martin,

Hood, Tressa,

Muth, John,

Lowenberg, Bob,

Rettig, Michael P

2019

Overview

This study dissected the complexity of the immune architecture of acute myeloid leukemia (AML) at high resolution and assessed its influence on therapeutic response. Using 387 primary bone marrow samples from three discovery cohorts of children and adults with AML, we defined immune-infiltrated and immune-depleted disease subtypes and unraveled critical differences in immune gene expression across age groups and disease stages. Importantly, interferon (IFN)-γ-related mRNA profiles were predictive for both chemotherapy resistance and response of primary refractory/relapsed AML to flotetuzumab immunotherapy. Our compendium of microenvironmental gene and protein profiles sheds novel insights into the immuno-biology of AML and will inform the delivery of personalized immunotherapies to IFN-γ-dominant AML subtypes.

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Publisher

Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory

Subject

Acute myeloid leukemia