Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

by Pan, Hui , Aryal, Pratik , Konkar, Anish , Kasif, Simon , Higgs, Brandon W , Foster, Kathleen , Dong, Xuehong , Patti, Mary Elizabeth , Kahn, Barbara B , Simonson, Donald C , Dreyfuss, Jonathan , Yang, Yixing , Vernon, Ashley , Goldfine, Allison , Grimsby, Joseph , Yinong Sebastian , Rondinone, Christina M

in Alanine / Blood glucose / Clinical trials / Diabetes mellitus (non-insulin dependent) / Gastric bypass / Gastrointestinal surgery / Growth hormones / Histidine / Hydroxyproline / Insulin / Isoleucine / Leucine / Menopause / Metabolism / Molecular modelling / Proteomes / Surgery / Systems Biology / Valine

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

2019

Confirm

Do you wish to request the book?

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Paper

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

Pan, Hui,

Aryal, Pratik,

Konkar, Anish,

Kasif, Simon,

Higgs, Brandon W,

Foster, Kathleen,

Dong, Xuehong,

Patti, Mary Elizabeth,

Kahn, Barbara B,

Simonson, Donald C,

Dreyfuss, Jonathan,

Yang, Yixing,

Vernon, Ashley,

Goldfine, Allison,

Grimsby, Joseph,

Yinong Sebastian,

Rondinone, Christina M

2019

Overview

Molecular mechanisms by which Roux-en-Y gastric bypass (RYGB) improves glycemic control and metabolism in type 2 diabetes (T2D) remain incompletely understood. In the SLIMM-T2D trial, participants with T2D were randomized to RYGB or nonsurgical management and their fasting plasma proteome and metabolome were analyzed for up to 3 years. To identify analytes that mediate improvement in outcomes, we developed a high-throughput mediation analysis method (Hitman), which is significantly more powerful than existing methods. Top-ranking analyte mediators of glycemia improvement were growth hormone receptor and prolyl-hydroxyproline, which were more significant than any clinical mediator, including BMI. Beta-alanine and Histidine Metabolism (both including CNDP1) were top differentially regulated pathways, and Valine, Leucine and Isoleucine Degradation was also a top differentially-regulated pathway and a top mediator of improvement in insulin resistance. The identified analytes may serve as novel targets for T2D therapy. More broadly, Hitman can identify analyte mediators of outcomes in randomized trials for which high-throughput data are available. Footnotes * https://github.com/jdreyf/slimm-t2d-omics

Share this book

Add to My Shelf

Publisher

Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory

Subject

Alanine

/ Blood glucose

/ Clinical trials

/ Diabetes mellitus (non-insulin dependent)

/ Gastric bypass

/ Gastrointestinal surgery

/ Growth hormones