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Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males
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Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males
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Journal Article
Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males
2013
Overview
•qHPV efficacy against EGL and intra-anal disease related to HPV in men has been demonstrated.•We examine efficacy against disease due to 10 additional non-vaccine HPV types.•Vaccinating men against HPV 6/11/16/18 protects against most vaccine HPV-type related anogenital disease.•Significant efficacy against disease due to non-vaccine HPV types was not seen.•No evidence of increased disease caused by non-vaccine types was evident.
A small number of HPV types are related to a majority of HPV-related neoplastic lesions in humans. High-risk types such as HPV 16 and 18 are most often implicated, although other oncogenic and non-oncogenic HPV types can cause disease in men. The efficacy of the quadrivalent HPV vaccine (qHPV) against external genital lesions and intra-anal disease related to HPV in men has been demonstrated. This report examines the vaccine's efficacy against disease due to 10 additional non-vaccine HPV types, as well as efficacy regardless of HPV detection. The data presented suggest that vaccinating males against HPV 6, 11, 16 and 18 protects them against most vaccine HPV-type related anogenital disease. However, significant efficacy against disease due to non-vaccine HPV types was not seen. In addition, the data do not provide any evidence that vaccination with qHPV vaccine will increase the likelihood of disease caused by non-vaccine types in the short term.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Adult
/ Anus Neoplasms - epidemiology
/ Biological and medical sciences
/ Fundamental and applied biological sciences. Psychology
/ Genital Neoplasms, Male - pathology
/ Genital Neoplasms, Male - prevention & control
/ Genital Neoplasms, Male - virology
/ HPV
/ Human papillomavirus 11 - pathogenicity
/ Human papillomavirus 16 - pathogenicity
/ Human papillomavirus 18 - pathogenicity
/ Human papillomavirus 6 - pathogenicity
/ Humans
/ Lesions
/ Male
/ Males
/ men
/ Papillomavirus Infections - epidemiology
/ Papillomavirus Infections - prevention & control
/ Papillomavirus Infections - virology
/ Papillomavirus Vaccines - therapeutic use
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ Young
