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Proliferating toward sex: characterization of cell division of Toxoplasma gondii ’s pre-sexual stages
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Proliferating toward sex: characterization of cell division of Toxoplasma gondii ’s pre-sexual stages
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Journal Article
Proliferating toward sex: characterization of cell division of Toxoplasma gondii ’s pre-sexual stages
2026
Overview
Sexual development in Toxoplasma gondii is essential for transmission, but remains poorly understood, largely because pre-sexual stages are restricted to the feline intestine and have only recently become experimentally accessible. Here, we leverage an in vitro differentiation system to resolve how parasites transition toward merozoite formation at the cellular level. By combining expansion microscopy, stage-specific markers, and quantitative analyses, we define the temporal sequence of nuclear division and daughter cell assembly during merogony, addressing longstanding ambiguity regarding division modes in these stages. Our findings reveal that parasites can adopt alternative division strategies emerging from a polyploid intermediate, highlighting an unexpected degree of flexibility in how cell division is executed during differentiation. Beyond refining this developmental framework, this work establishes a foundation for future mechanistic studies of pre-sexual biology and provides broader insight into the diversity of eukaryotic cell division strategies.
