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Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae
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Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae
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Journal Article
Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae
1999
Overview
The human adenovirus serotype 5 (Ad5) is used widely for applications in human gene therapy. Cellular attachment of Ad5 is mediated by binding of the carboxyl-terminal knob of its fiber coat protein to the Coxsackie adenovirus receptor (CAR) protein. However, Ad5 binding to CAR hampers the development of adenovirus vectors capable of specifically targeting (diseased) tissues or organs. Through sequence analysis and mutagenesis, a conserved receptor-binding region was identified on the side of three divergent CAR-binding knobs. The feasibility of simultaneous CAR ablation and redirection of an adenovirus to a new receptor is demonstrated.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Adenoviruses, Human - chemistry
/ Adenoviruses, Human - metabolism
/ Biological and medical sciences
/ Cells
/ Coxsackie and Adenovirus Receptor-Like Membrane Protein
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ Humans
/ Lectins
/ Protein Structure, Secondary
/ Proteins
/ Receptors, Virus - metabolism
/ Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
/ Scars
/ Trimers
/ Virology
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