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Vitamina D: la deficiencia invisible que compromete la salud integral
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Vitamina D: la deficiencia invisible que compromete la salud integral
Vitamina D: la deficiencia invisible que compromete la salud integral
Journal Article

Vitamina D: la deficiencia invisible que compromete la salud integral

2025
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Overview
La deficiencia de vitamina D representa una de las condiciones carenciales más comunes a nivel mundial, afectando a millones de personas en todos los grupos etarios y en múltiples contextos clínicos. A pesar de su alta prevalencia, continúa siendo subdiagnosticada y subtratada, en parte debido a su curso silencioso, a la escasa incorporación de su tamizaje en la práctica médica rutinaria y a la persistente percepción de que sus consecuencias clínicas se limitan al metabolismo óseo. Esta mirada reduccionista ha contribuido a que se desaproveche una herramienta terapéutica segura, accesible y con amplio potencial preventivo y pronóstico en distintas enfermedades crónicas.Durante décadas, el déficit de vitamina D estuvo principalmente vinculado al raquitismo infantil y a la osteomalacia en adultos, sin embargo, avances en la investigación han demostrado que la vitamina D posee receptores en múltiples tejidos, ejerciendo funciones endocrinas, paracrinas e inmunomoduladoras que trascienden su rol en la homeostasis del calcio y el fósforo. Actualmente, se reconoce que niveles bajos de 25-hidroxivitamina D están asociados no solo a fragilidad ósea, caídas y fracturas, sino también a sarcopenia, debilidad muscular, alteraciones inmunológicas, disfunción metabólica, neurocognitiva y emocional, entre otros desenlaces adversos.
Publisher
Asociación Colombiana de Endocrinología