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Dynamic complex formation during the yeast cell cycle

by Jensen, L.J , Bork, P , Brunak, S , Lichtenberg, U. de

in Biological and medical sciences / Biological systems / CDC28 Protein Kinase, S cerevisiae - metabolism / Cell Cycle / Cell cycle proteins / Cell Cycle Proteins - genetics / Cell Cycle Proteins - metabolism / Cells / Cells (Biology) / Cyclins / Cyclins - metabolism / Cytoskeleton - metabolism / DNA / DNA Repair / DNA Replication / Fundamental and applied biological sciences. Psychology / fungal proteins / Gene expression / Gene expression regulation / Gene Expression Regulation, Fungal / Genes / Genes, Fungal / Genetics / Growth, nutrition, metabolism, transports, enzymes. Molecular biology / Interphase / Meta Analysis / Microbiology / Mitosis / Mycology / Networks / Nucleosomes / Oligonucleotide Array Sequence Analysis / Phosphorylation / protein aggregates / protein complexes / protein degradation / Protein Interaction Mapping / protein phosphorylation / Protein Subunits - metabolism / Proteins / Saccharomyces cerevisiae / Saccharomyces cerevisiae - cytology / Saccharomyces cerevisiae - genetics / Saccharomyces cerevisiae - metabolism / Saccharomyces cerevisiae Proteins - genetics / Saccharomyces cerevisiae Proteins - metabolism / Topology / Transcription, Genetic / Transcriptional regulatory elements / Yeast / Yeasts

2005

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Dynamic complex formation during the yeast cell cycle

by Jensen, L.J , Bork, P , Brunak, S , Lichtenberg, U. de

2005

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Dynamic complex formation during the yeast cell cycle

by Jensen, L.J , Bork, P , Brunak, S , Lichtenberg, U. de

2005

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Journal Article

Dynamic complex formation during the yeast cell cycle

Jensen, L.J,

Bork, P,

Brunak, S,

Lichtenberg, U. de

2005

Overview

To analyze the dynamics of protein complexes during the yeast cell cycle, we integrated data on protein interactions and gene expression. The resulting time-dependent interaction network places both periodically and constitutively expressed proteins in a temporal cell cycle context, thereby revealing previously unknown components and modules. We discovered that most complexes consist of both periodically and constitutively expressed subunits, which suggests that the former control complex activity by a mechanism of just-in-time assembly. Consistent with this, we show that additional regulation through targeted degradation and phosphorylation by Cdc28p (Cdk1) specifically affects the periodically expressed proteins.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Biological and medical sciences

/ Biological systems

/ CDC28 Protein Kinase, S cerevisiae - metabolism

/ Cell Cycle

/ Cell cycle proteins

/ Cell Cycle Proteins - genetics

/ Cell Cycle Proteins - metabolism