Journal Article

Crystal structure of pomalidomide Form I, C 13 H 11 N 3 O 4

Kaduk, James A., Gindhart, Amy M., Blanton, Thomas N.

2021

Overview

The crystal structure of pomalidomide Form I has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Pomalidomide Form I crystallizes in the space group P -1 (#2) with a = 7.04742(9), b = 7.89103(27), c = 11.3106(6) Å, α = 73.2499(13), β = 80.9198(9), γ = 88.5969(6)°, V = 594.618(8) Å 3 , and Z = 2. The crystal structure is characterized by the parallel stacking of planes parallel to the bc -plane. Hydrogen bonds link the molecules into double layers also parallel to the bc -plane. Each of the amine hydrogen atoms acts as a donor to a carbonyl group in an N–H⋯O hydrogen bond, but only two of the four carbonyl groups act as acceptors in such hydrogen bonds. Other carbonyl groups participate in C–H⋯O hydrogen bonds. The powder pattern has been submitted to ICDD® for inclusion in the Powder Diffraction File™ (PDF®).