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Cover Picture: Targeting the SOD1–MMP‐2–COLXVII axis: A therapeutic strategy for age‐related tissue degeneration (View 4/2025)
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Cover Picture: Targeting the SOD1–MMP‐2–COLXVII axis: A therapeutic strategy for age‐related tissue degeneration (View 4/2025)
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Cover Picture: Targeting the SOD1–MMP‐2–COLXVII axis: A therapeutic strategy for age‐related tissue degeneration (View 4/2025)
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Journal Article
Cover Picture: Targeting the SOD1–MMP‐2–COLXVII axis: A therapeutic strategy for age‐related tissue degeneration (View 4/2025)
2025
Overview
In the article Targeting the SOD1–MMP‐2–COLXVII axis: a therapeutic strategy for age‐related tissue degeneration, Juewon Kim and co‐authors explore how oxidative stress and ECM degradation drive tissue aging. This image portrays life's journey toward longevity as a series of stepping stones across a flowing river. Each stone represents factors such as health, habits, and resilience that influence aging. Sturdy stones symbolize vitality and wisdom, while cracked ones reflect vulnerability and decline. The river carries time, nutrients, and experience, nourishing the traveler. The image visually captures how targeting the SOD1‐MMP‐2‐COLXVII axis helps stabilize this path, promoting healthy aging through deliberate, restorative steps. It captures the dynamic, ever‐changing nature of life and the power of intentional choices in shaping a fulfilling, enduring journey.
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