Asset Details
Do you wish to reserve the book?
SOCS家族分子在肿瘤发生发展中的作用
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
SOCS家族分子在肿瘤发生发展中的作用
Do you wish to request the book?
SOCS家族分子在肿瘤发生发展中的作用
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
SOCS家族分子在肿瘤发生发展中的作用
2016
Overview
细胞因子信号转导抑制分子（suppressor of cytokine signaling,SOCS）是一类在细胞信号转导过程中发挥重要作用的负调控因子,家族成员一共有8个,主要通过抑制JAK-STAT信号通路的持续激活而调节细胞的增殖、分化和凋亡。在肿瘤的发生发展过程中,由于SOCS家族基因启动子区CG岛超甲基化、组蛋白异常乙酰化、基因突变、基因缺失等原因导致的SOCS蛋白表达异常,使JAK-STAT被持续活化,从而导致肿瘤的发生发展与转移。本文综述了SOCS家族的发现,成员构成及分子结构,各结构域的功能及其在肿瘤发生发展等方面的最新进展。由于SOCS在肿瘤发生、发展方面的重要作用,SOCS分子作为信号转导途径重要的负调节因子发挥肿瘤抑制作用,使其成为肿瘤治疗的新靶标。
Publisher
天津医科大学总医院肺部肿瘤外科,天津,300052%300052 天津，天津市肺癌研究所，天津市肺癌转移与肿瘤微环境实验室，天津医科大学总医院%300052天津，天津医科大学总医院肺部肿瘤外科,300052 天津，天津市肺癌研究所，天津市肺癌转移与肿瘤微环境实验室，天津医科大学总医院,中国肺癌杂志编辑部
Subject
