Asset Details
Do you wish to reserve the book?
Catalytic Phosphorylation of Tyrosine via a Radical Arbuzov Reaction
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Catalytic Phosphorylation of Tyrosine via a Radical Arbuzov Reaction
Do you wish to request the book?
Catalytic Phosphorylation of Tyrosine via a Radical Arbuzov Reaction
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Paper
Catalytic Phosphorylation of Tyrosine via a Radical Arbuzov Reaction
2024
Overview
Synthetic protein/peptide modification is a powerful strategy for the development of new therapeutics and tools for chemical biology. Accordingly, the development of a synthetic variant of biological tyrosine phosphorylation, a cornerstone of the post-translational modification landscape, could find widespread application in the study of this fundamental biochemical signal. This work describes the development of a mechanistically-novel, redox-neutral, photocatalytic tyrosine phosphorylation reaction via a radical Arbuzov-type mechanism. The reaction proceeds with good tyrosine selectivity in di-, tri- and oligopeptides under mild conditions near neutral pH, tolerating potentially problematic functionality. As the first photocatalytic tyrosine phosphorylation reaction, this work represents a major advance towards the goal of synthetic tyrosine phosphorylation.
Publisher
American Chemical Society
Subject
