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Fabrication of Dolutegravir Sodium Cocrystals: Characterization, In vitro, In vivo Evaluation of Cocrystal Suspension Formulation
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Fabrication of Dolutegravir Sodium Cocrystals: Characterization, In vitro, In vivo Evaluation of Cocrystal Suspension Formulation
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Fabrication of Dolutegravir Sodium Cocrystals: Characterization, In vitro, In vivo Evaluation of Cocrystal Suspension Formulation
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Journal Article
Fabrication of Dolutegravir Sodium Cocrystals: Characterization, In vitro, In vivo Evaluation of Cocrystal Suspension Formulation
2025
Overview
The objective of this research was to increase the solubility of Antiretroviral Dolutegravir sodium (DGS), drug by utilizing co-crystallization technique as well formulating Suspension of Dolutegravir sodium cocrystals to enhance the therapeutic effectiveness. Dolutegravir Sodium (DGS) and Salicylic acid cocrystal were created in 1:1 ratio utilizing ethanol as solvent-by-solvent evaporation technique. Developed Cocrystals of Dolutegravir Sodium (DGS) and Salicylic acid assessed for preliminary characterization by utilizing PXRD, DCS, FTIR and SEM. Suspension that contained DGS cocrystals characterized for Dissolution rate, Drug content, Flow rate and Stability study. The findings indicated that the prepared suspension exhibited satisfactory characteristics and remained stable under the testing conditions. In vivo results demonstrate that the tested formulation exhibit quicker absorption compared to the formulation used as control. Hence it can be inferred that Suspension composed of Dolutegravir sodium (DGS) cocrystals shows improved therapeutic performance.
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