Journal Article

CSF-Tau and CSF-Aβ1–42 in Posterior Cortical Atrophy

Sollberger, Marc, Gomez-Mancilla, Baltazar, Kuhle, Jens, Regeniter, Axel, Schmidtke, Klaus, Baumann, Thomas P., Duyar, Hüseyin, Monsch, Andreas U.

2010

Overview

Objective: Our purpose was to measure Aβ 1–42 , T-tau and P-tau 181 in the cerebrospinal fluid (CSF) of patients with posterior cortical atrophy (PCA), a presenile dementia likely to represent a variant of Alzheimer’s disease (AD). Methods: CSF samples from 34 subjects including 9 patients with PCA, 11 age-matched patients with AD and 14 age-matched cognitively healthy controls were analyzed using commercially available ELISA kits. Results: The Aβ 1–42 , T-tau and P-tau 181 levels in PCA patients differed significantly (p < 0.02) from those in healthy controls but were indistinguishable from subjects with a clinical diagnosis of AD. Conclusion: High T-tau and P-tau 181 and low Aβ 1–42 levels in PCA – typically observed in AD – indicate that the underlying pathology of PCA is usually AD. If these findings are replicated in PCA patients with autopsy-confirmed AD neuropathology, PCA patients may be eligible for disease-modifying AD treatments.

• Publisher: Karger
• Subject: Biological and medical sciences / Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases / Investigative techniques, diagnostic techniques (general aspects) / Medical sciences / Nervous system / Neurology / Original Research Article / Radionuclide investigations