Asset Details
Do you wish to reserve the book?
Interwoven control of histone lactylation: metabolic enzymes LDHA/ACSS2 couple with epigenetic writer KAT2A
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Interwoven control of histone lactylation: metabolic enzymes LDHA/ACSS2 couple with epigenetic writer KAT2A
Do you wish to request the book?
Interwoven control of histone lactylation: metabolic enzymes LDHA/ACSS2 couple with epigenetic writer KAT2A
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Interwoven control of histone lactylation: metabolic enzymes LDHA/ACSS2 couple with epigenetic writer KAT2A
2026
Overview
Histone lactylation is critically involved in the regulation of gene expression and the modulation of diverse cellular processes in both normal and tumor cells. A recent study by Zhu et al. [Cell Metab. 37 , 361–376] demonstrated that ACSS2 functions as a bona fide lactyl-CoA synthetase, converting lactate into lactyl-CoA. In response to elevated aerobic glycolysis and EGFR activation, ERK-mediated phosphorylation drives the nuclear translocation of ACSS2, promoting the formation of the ACSS2–KAT2A complex. KAT2A utilizes ACSS2-derived lactyl-CoA and acts as a lactyltransferase to promote histone lactylation, gene expression, tumor growth, and immune evasion.
Publisher
EDP Sciences
Subject
We currently cannot retrieve any items related to this title. Kindly check back at a later time.