Journal Article

Construction of virtual whole eye model based on ultra-widefield optical coherence tomography in myopia

Wu, Pengsen, Liu, Meizhou, Chen, Caiyi, Guo, Wenjun, Huo, Li, Zhang, Shaochong, Shen, Yitong, Jiang, Juntao, Tang, Xiangcheng, FU, Mingzhu, Pan, Xingzheng, Liu, Guiqin, Mu, Jingfeng, Luo, Na, Chi, Wei

2026

Overview

Recognizing the inconvenience of magnetic resonance imaging (MRI) in evaluating the ocular morphology, this study developed a three-dimensional virtual whole eye model (CET-1) using ultra-widefield swept-source optical coherence tomography. The CET-1 were validated with MRI models in 80 eyes from 40 individuals with different extent of myopia. The result showed these two models have high consistency across different axial lengths (22.19 to 32.56 mm) -calculated as the mean point-to-surface distance, measuring 0.0183 ± 0.0025 normalized unit (439.57 ± 59.87 μm). Compared to the normal group, both of the posterior segment Gaussian curvature and anterior segment parameters demonstrated a significant change in myopic groups (P < 0.05). The CET-1 model provides a simple and effective tool that enables the establishment of a digital twin ocular model, facilitating the monitoring and quantitative analysis of myopia development and progression. Thus, supports optimized treatment strategies and contributes to the advancement of personalized medicine.