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A new secondary metabolite isolated from endophytic fungus Paraconiothyrium brasiliense associated with Dendrobium huoshanense
by
He, Yi
, Li, Kenou
, Liu, jikai
, Feng, Yuanyuan
, xu, Feng
, zhu, Xinyao
, Yang, Huixiang
2026
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A new secondary metabolite isolated from endophytic fungus Paraconiothyrium brasiliense associated with Dendrobium huoshanense
by
He, Yi
, Li, Kenou
, Liu, jikai
, Feng, Yuanyuan
, xu, Feng
, zhu, Xinyao
, Yang, Huixiang
2026
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A new secondary metabolite isolated from endophytic fungus Paraconiothyrium brasiliense associated with Dendrobium huoshanense
Journal Article
A new secondary metabolite isolated from endophytic fungus Paraconiothyrium brasiliense associated with Dendrobium huoshanense
2026
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Overview
ix compounds were isolated from the endophytic fungus Paraconiothyrium brasiliense associated with Dendrobium huoshanense, including a new depsidone derivative, named as paraconbrasin A (1). Their chemical structures were characterized using MS, NMR, and X-ray single crystal diffraction. All isolates were evaluated for their anti-inflammatory activities in vitro, and 1 and 4 exhibited moderate inhibitory activities against nitric oxide production in lipopolysaccharide-induced RAW264.7 mouse macrophages with IC50 values of 21.05 ± 3.66 μM and 12.24 ± 0.39 μM, respectively. These findings provide new clues for the future design of novel anti-inflammatory agents.
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