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Predicting Mortality in Gastrointestinal Bleeding: Serum Copeptin Levels or Age, Systolic Blood Pressure and Shock Index-A Cross-Sectional Study
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Predicting Mortality in Gastrointestinal Bleeding: Serum Copeptin Levels or Age, Systolic Blood Pressure and Shock Index-A Cross-Sectional Study
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Journal Article
Predicting Mortality in Gastrointestinal Bleeding: Serum Copeptin Levels or Age, Systolic Blood Pressure and Shock Index-A Cross-Sectional Study
2026
Overview
Aim: Vital signs, blood parameters, and some blood biomarkers in patients with gastrointestinal (GI) bleeding vary depending on the severity of the bleeding. The aim of this study is to investigate the association of vital signs and copeptin levels with transfusion requirements, and patient prognosis, including hospitalization duration and 30-day mortality. Materials and Methods: Prospective, cross-sectional, observational study, conducted in the emergency department (ED) of a tertiary care university hospital, between June 2021 and May 2022. Admission serum copeptin levels and vital parameters of patients with a diagnosis of GI bleeding were noted and evaluated in terms of outcome measures. Results: The study included 118 patients, 75 (63.6%) of whom were male. The median age was 72 years (interquartile range: 58-83). A total of 18 (15%) patients died within 30 days. Serum copeptin levels did not differ between deceased patients and survivors. Logistic regression analysis showed that a shock index above 0.70 and patients aged 75 years and older together [p=0.017, odds ratio (OR)=6.824; 95% confidence interval (CI): (1.419-32.811)] lead to an increase in 30-day mortality. Lower systolic blood pressure at the admission to the ED was associated with increased 30-day mortality [p=0.003, OR=0.952; 95% CI: (0.922-0.983)]. Conclusion: Although serum copeptin levels failed to predict 30-day mortality in patients admitted to the ED due to GI bleeding, our models demonstrated that age over 75 years, lower systolic blood pressure, and the shock index, were superior predictors of mortality.
Publisher
Emergency Medicine Physicians’ Association of Turkey
Subject
