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Journal Article
Coagulation and cognitive function - science behind the scenes
2022
Overview
Cardiovascular risk factors and proteins that regulate endothelial cell function have been suggested to contribute to the development of Alzheimer's disease (AD)-related dementia. The aim of the study was to investigate a relationship between vascular endothelial growth factor (VEGF), VEGF-interacting protein, neuropilin-1, and blood coagulation/anticoagulation proteins with cognitive decline associated with AD. Plasma levels of different proteins were measured in healthy volunteers (N=193), patients with mild cognitive impairment (N=126) and patients with probable AD (N=365).
Fibrinogen and coagulation factor XI were the highest in the probable AD group and were significantly different only from the values in the healthy volunteers group (p = 0.035 and p = 0.002, respectively). Coagulation factor X, coagulation factor Xa and protein C were the lowest in the probable AD group and the differences were significant only when compared with the values in the healthy volunteers group (p = 0.043, p = 0.003 and p = 0.008, respectively). There was significant, non-parametric correlation between VEGF and neuropilin-1 and coagulation/anticoagulation proteins: neuropilin-1 and protein C (r = - 0.274, p = 0.000), neuropilin-1 and fibrinogen (r = 0.209, p = 0.000), neuropilin-1 and coagulation factor X (r = - 0.220, p = 0.000), neuropilin-1 and coagulation factor Xa (r = - 0.247, p = 0.000), VEGF and protein C (r = - 0.191, p = 0.000).
Our results demonstrate significant differences in plasma levels of some coagulation/anticoagulation proteins between AD patients and healthy individuals, indicating a specific pattern of hypercoagulability risk in the AD patients.
Publisher
Elsevier Inc,Elsevier Limited
Subject
/ Proteins
