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Fenfluramine: An Uncommon Cause of False Positive Urine Drug Testing: A Case Report
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Journal Article
Fenfluramine: An Uncommon Cause of False Positive Urine Drug Testing: A Case Report
2025
Overview
ABSTRACT
Background
Fenfluramine is an antiseizure medication approved by the Food and Drug Administration for the treatment of Dravet syndrome in patients older than 2 years. Fenfluramine is an amphetamine derivative. It cross‐reacts with amphetamines in urine drug screen immunoassays.
Patient Presentation
A 2‐year‐old patient with Dravet syndrome had a cardiorespiratory arrest and tested positive for amphetamines in a urine drug screen, raising concerns of child abuse. Liquid chromatography–mass spectrometry confirmed the presence of fenfluramine but did not detect amphetamines.
Conclusion
Fenfluramine can result in a false‐positive amphetamine urine drug screen at the recommended dose for Dravet syndrome. Awareness of this potential cross‐reactivity can prevent undue child protective services reports, especially in patients at high risk for sudden death.
Publisher
Wiley
Subject
