Asset Details
Do you wish to reserve the book?
Case Report of Giant Myxoid Fibrosarcomatous Dermatofibrosarcoma Protuberans Compressing the Right Jugular Vein: A Multidisciplinary Approach to Complex Surgical Management
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Case Report of Giant Myxoid Fibrosarcomatous Dermatofibrosarcoma Protuberans Compressing the Right Jugular Vein: A Multidisciplinary Approach to Complex Surgical Management
Do you wish to request the book?
Case Report of Giant Myxoid Fibrosarcomatous Dermatofibrosarcoma Protuberans Compressing the Right Jugular Vein: A Multidisciplinary Approach to Complex Surgical Management
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Case Report of Giant Myxoid Fibrosarcomatous Dermatofibrosarcoma Protuberans Compressing the Right Jugular Vein: A Multidisciplinary Approach to Complex Surgical Management
2026
Overview
Introduction: Dermatofibrosarcoma protuberans (DFSP) is a slow-growing cutaneous neoplasm with high cure rates following complete surgical resection. However, 5-15% of classic DFSP cases undergo fibrosarcomatous transformation, resulting in fibrosarcomatous DFSP (FS-DFSP), a more aggressive variant with significantly higher rates of local recurrence, metastasis, and mortality. This case presents a rare myxoid variant of FS-DFSP with complex anatomical involvement requiring multidisciplinary management. Case Presentation: A 56-year-old female presented with a giant recurrent chest mass measuring 15 × 12 × 6 cm, initially misdiagnosed as fibroma 19 years prior. Advanced imaging revealed an 8 × 13 × 12 cm poorly defined soft tissue mass involving the pectoralis major and extending to the sternocleidomastoid muscles, with compression of the proximal right jugular vein. Histopathological examination confirmed FS-DFSP with myxoid differentiation, characterized by diffuse spindle cell infiltration in a herringbone pattern. Immunohistochemistry revealed CD34+, EMA+, and Actin+ staining with negative desmin, S100, and STAT-6. COL1A1-FISH analysis demonstrated COL1A1/PDGFB fusion in 8% of cells. Management included tumor vascular embolization, surgical resection with 3 cm margins, skin grafting, local flap repair, and adjuvant radiation therapy due to anatomical constraints and residual tumor involvement of the anterior sternum. Conclusion: This case highlights the myxoid variant of FS-DFSP, emphasizing the importance of comprehensive histopathological evaluation, multidisciplinary treatment planning, and long-term surveillance. The successful management with combined surgical and radiation therapy demonstrates the need for individualized treatment approaches in complex anatomical locations. Four-year follow-up shows no evidence of recurrence, supporting the efficacy of aggressive multimodal therapy in preventing local recurrence in FS-DFSP.
Publisher
Karger Publishers
Subject
