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Lack of Activity of Amphotericin B in Systemic Murine Fusarial Infection
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Lack of Activity of Amphotericin B in Systemic Murine Fusarial Infection
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Journal Article
Lack of Activity of Amphotericin B in Systemic Murine Fusarial Infection
1992
Overview
Systemic fusarial infections have emerged as a significant cause of mortality in cancer patients. Yet, little is known about the management of these infections. The in vivo antifungal activity of amphotericin B in CF1 mice with disseminated fusarial infections was studied. Two pathogenic strains of Fusarium solani were used. Intraperitoneal administration of amphotericin B in daily doses of 0.5, 1, and 2 mg/kg for ⩽10 days did not prolong survival oftreated animals. Clearance of F. solani from kidneys was similar in mice treated with 1 mg/kg per day of amphotericin Band in untreated animals. These results are in agreement with the known in vitro and in vivo resistance of Fusarium species to amphotericin B.
Publisher
The University of Chicago Press
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