Asset Details
Do you wish to reserve the book?
Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder in a Young Japanese Male Patient
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder in a Young Japanese Male Patient
Do you wish to request the book?
Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder in a Young Japanese Male Patient
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder in a Young Japanese Male Patient
2025
Overview
A 34-year-old man became aware of an erythematous nodule on the left nasal wing. He was treated with topical steroids and oral antibacterial agents at his local doctor, but his condition did not improve, and he was referred to our hospital. A skin biopsy revealed diffuse cellular infiltration through the dermis. No epidermotropism was seen. The major infiltrate was small to medium-sized lymphoid cells. The number of CD3+ cells was almost the same as that of CD20+ cells, while CD4+ cells were dominant over CD8+ cells. Atypical lymphocytes were positive for BCL6 and PD-1. Polymerase chain reaction (PCR) analysis of immunoglobulin heavy chain and T-cell receptor gene rearrangements on paraffin-embedded tissue sections revealed a clonal expansion of T-cells. The patient was diagnosed as having primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PCSM-LPD) and treated with fludroxycortide tape. The red nodule completely disappeared after three months. Nuclear staining for nuclear factor of activated T-cells c1 (NFATc1), which had been suggested to be useful in distinguishing PCSM-LPD from pseudolymphoma, was negative in our case. Our case was considered to be typical of PCSM-LPD among existing reports of PCSM-LPD from Japan, except for the young age of the patient. Our case suggested that young cases with PCSM-LPD may have been misdiagnosed with cutaneous pseudolymphoma (CPL), which may be one of the reasons why this type of lymphoproliferative disorder has been reported to occur in elderly people.
