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Rational bioengineering of polysaccharide in designing of microbiome modulation
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Journal Article
Rational bioengineering of polysaccharide in designing of microbiome modulation
2025
Overview
HighlightsPolysaccharides serve as effective prebiotics by promoting the growth of beneficial bacteria and stimulating short-chain fatty acid production, thereby reshaping the gut microbial environment. Polysaccharides are well-suited for oral administration because of their resistance to enzymatic degradation in the gastrointestinal tract and selective degradation in the intestine, enabling targeted and effective modulation of the gut microbiome. Polysaccharides exhibit dual functionality as prebiotics and immunomodulators, shaping the gut microbial environment and enhancing therapeutic effects. Polysaccharides exhibit versatile physicochemical and biological properties because of their diverse chemical functionalities and structures, enabling bioengineering modifications for effective microbiome modulation.
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