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Enhanced Expression of β 2-microglobulin and HLA Antigens on Human Lymphoid Cells by Interferon
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Enhanced Expression of β 2-microglobulin and HLA Antigens on Human Lymphoid Cells by Interferon
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Journal Article
Enhanced Expression of β 2-microglobulin and HLA Antigens on Human Lymphoid Cells by Interferon
1978
Overview
Mononuclear cells from the blood of healthy normal humans were kept in cultures under nonstimulating conditions for 16 hr in the presence or absence of human interferon. The relative quantities of HLA antigens and β 2-microglobulin on the cultured cells were determined by quantitative immunofluorescence (fluorescence-activated cell sorter) and by the capacity of cells to absorb out cytotoxic antibodies against the relevant antigens. Interferons of different origin and purities enhanced the expression of HLA antigens and β 2-microglobulins, whereas membrane immunoglobulins and antigens recognized by antiserum raised against human brain and T cells were the same on interferon-treated and control cells. Similar interferon effects were observed on an Epstein-Barr virus-negative Burkitt lymphoma cell line. The enhanced expression of histocompatibility antigen subsequent to interferon treatment was observed on B- and T-enriched lymphocyte populations and was found to be dose dependent with the optimum with ``physiological'' concentration of interferon. Pretreatment of lymphocytes with interferon for 2 hr was found to be as effective as having interferon present during the total culture period. The interferon-induced enhancement of antigen expression on cells was dependent on active protein synthesis.
Publisher
National Academy of Sciences of the United States of America
Subject
