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H1N1pdm09 Influenza Virus and Its Descendants Lack Extra-epitopic Amino Acid Residues Associated With Reduced Recognition by M158-66-Specific CD8+ T Cells

by Koopmans, Marion P G , Pronk, Mark R , Fouchier, Ron A M , Rimmelzwaan, Guus F , Sagong, Kyung A , Bestebroer, Theo M , Spronken, Monique I , van de Sandt, Carolien E

in Major and Brief Reports

2018

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Journal Article

H1N1pdm09 Influenza Virus and Its Descendants Lack Extra-epitopic Amino Acid Residues Associated With Reduced Recognition by M158-66-Specific CD8+ T Cells

Koopmans, Marion P G,

Pronk, Mark R,

Fouchier, Ron A M,

Rimmelzwaan, Guus F,

Sagong, Kyung A,

Bestebroer, Theo M,

Spronken, Monique I,

van de Sandt, Carolien E

2018

Overview

Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During >6 years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated 4 other amino acid substitutions. However, these did not affect M158-66-specific CTL activation.

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Publisher

Oxford University Press

Subject

Major and Brief Reports